cit (1.7)

0 users

Causal Inference Test.

A likelihood-based hypothesis testing approach is implemented for assessing causal mediation. For example, it could be used to test for mediation of a known causal association between a DNA variant, the 'instrumental variable', and a clinical outcome or phenotype by gene expression or DNA methylation, the potential mediator. Another example would be testing mediation of the effect of a drug on a clinical outcome by the molecular target. The hypothesis test generates a p-value or permutation-based FDR value with confidence intervals to quantify uncertainty in the causal inference. The outcome can be represented by either a continuous or binary variable, the potential mediator is continuous, and the instrumental variable can be continuous or binary and is not limited to a single variable but may be a design matrix representing multiple variables.

Maintainer: Joshua Millstein
Author(s): Joshua Millstein

License: Artistic-2.0

Uses: Does not use any package

Released about 1 month ago.

6 previous versions



  (0 votes)


  (0 votes)

Log in to vote.


No one has written a review of cit yet. Want to be the first? Write one now.

Related packages:(20 best matches, based on common tags.)

Search for cit on google, google scholar, r-help, r-devel.

Visit cit on R Graphical Manual.