cit (2.0)
Causal Inference Test.
http://cran.rproject.org/web/packages/cit
A likelihoodbased hypothesis testing approach is implemented for assessing causal mediation. For example, it could be used to test for mediation of a known causal association between a DNA variant, the 'instrumental variable', and a clinical outcome or phenotype by gene expression or DNA methylation, the potential mediator. Another example would be testing mediation of the effect of a drug on a clinical outcome by the molecular target. The hypothesis test generates a pvalue or permutationbased FDR value with confidence intervals to quantify uncertainty in the causal inference. The outcome can be represented by either a continuous or binary variable, the potential mediator is continuous, and the instrumental variable can be continuous or binary and is not limited to a single variable but may be a design matrix representing multiple variables.
Maintainer:
Joshua Millstein
Author(s): Joshua Millstein
License: Artistic2.0
Uses: Does not use any package
Released 8 months ago.
9 previous versions
 cit_1.9. Released 10 months ago.
 cit_1.8. Released 10 months ago.
 cit_1.7. Released 12 months ago.
 cit_1.5. Released 12 months ago.
 cit_1.4. Released over 1 year ago.
 cit_1.3. Released almost 2 years ago.
 cit_1.2. Released almost 3 years ago.
 cit_1.1. Released almost 5 years ago.
 cit_1.0. Released about 5 years ago.
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