GSSE (0.1)

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Genotype-Specific Survival Estimation.

We propose a fully efficient sieve maximum likelihood method to estimate genotype-specific distribution of time-to-event outcomes under a nonparametric model. We can handle missing genotypes in pedigrees. We estimate the time-dependent hazard ratio between two genetic mutation groups using B-splines, while applying nonparametric maximum likelihood estimation to the reference baseline hazard function. The estimators are calculated via an expectation-maximization algorithm.

Maintainer: Baosheng Liang
Author(s): Baosheng Liang, Yuanjia Wang and Donglin Zeng

License: GPL (>= 2)

Uses: Iso, zoo, MASS

Released over 4 years ago.



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