IAbin (1.0)

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Plotting N-T Plane for Decision on Performing an Interim Analysis.


In randomized-controlled trials, interim analyses are often planned for possible early trial termination to claim superiority or futility of a new therapy. Blinded data also have information about the potential treatment difference between the groups. We developed a blinded data monitoring tool that enables investigators to predict whether they observe such an unblinded interim analysis results that supports early termination of the trial. Investigators may skip some of the planned interim analyses if an early termination is unlikely. This tool will provide reference information about N: Sample size at interim analysis, and T: Total number of responders at interim analysis for decision on performing an interim analysis.

Maintainer: Kyongsun Pak
Author(s): Kyongsun Pak

License: GPL (>= 2)

Uses: testthat, evaluate, knitr

Released over 2 years ago.



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