LEANR (1.4.9)

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Finds "Local Subnetworks" Within an Interaction Network which Show Enrichment for Differentially Expressed Genes.


Implements the method described in "Network-based analysis of omics data: The LEAN method" [Gwinner Boulday (2016) ] Given a protein interaction network and a list of p-values describing a measure of interest (as e.g. differential gene expression) this method computes an enrichment p-value for the protein neighborhood of each gene and compares it to a background distribution of randomly drawn p-values. The resulting scores are corrected for multiple testing and significant hits are returned in tabular format.

Maintainer: Frederik Gwinner
Author(s): Frederik Gwinner

License: GPL-3

Uses: ROCR, doMC, testthat, knitr, rmarkdown

Released over 1 year ago.



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