MetaSubtract (1.1)

Subtracting Summary Statistics of One or more Cohorts from Meta-GWAS Results.

If results from a meta-GWAS are used for validation in one of the cohorts that was included in the meta-analysis, this will yield biased (i.e. too optimistic) results. The validation cohort needs to be independent from the meta-GWAS results. MetaSubtract will subtract the results of the respective cohort from the meta-GWAS results analytically without having to redo the meta-GWAS analysis using the leave-one-out methodology. It can handle different meta-analyses methods and takes into account if single or double genomic control correction was applied to the original meta-analysis. It can be used for whole GWAS, but also for a limited set of SNPs or other genetic markers.

Maintainer: Ilja M. Nolte
Author(s): Ilja M. Nolte

License: GPL (>= 3)

Uses: Does not use any package

Released over 2 years ago.