NNTbiomarker (0.29.11)

0 users

Calculate Design Parameters for Biomarker Validation Studies.


Helps a clinical trial team discuss the clinical goals of a well-defined biomarker with a diagnostic, staging, prognostic, or predictive purpose. From this discussion will come a statistical plan for a (non-randomized) validation trial. Both prospective and retrospective trials are supported. In a specific focused discussion, investigators should determine the range of "discomfort" for the NNT, number needed to treat. The meaning of the discomfort range, [NNTlower, NNTupper], is that within this range most physicians would feel discomfort either in treating or withholding treatment. A pair of NNT values bracketing that range, NNTpos and NNTneg, become the targets of the study's design. If the trial can demonstrate that a positive biomarker test yields an NNT less than NNTlower, and that a negative biomarker test yields an NNT less than NNTlower, then the biomarker may be useful for patients. A highlight of the package is visualization of a "contra-Bayes" theorem, which produces criteria for retrospective case-controls studies.

Maintainer: Roger Day
Author(s): Roger Day

License: GPL-3

Uses: magrittr, mvbutils, shiny, stringr, xtable, ggplot2, plyr, testthat, knitr, rmarkdown

Released over 4 years ago.

1 previous version



  (0 votes)


  (0 votes)

Log in to vote.


No one has written a review of NNTbiomarker yet. Want to be the first? Write one now.

Related packages:(20 best matches, based on common tags.)

Search for NNTbiomarker on google, google scholar, r-help, r-devel.

Visit NNTbiomarker on R Graphical Manual.