POINT (1.1)

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Protein Structure Guided Local Test.


Provides an implementation of a rare variant association test that utilizes protein tertiary structure to increase signal and to identify likely causal variants. Performs structure-guided collapsing, which leads to local tests that borrow information from neighboring variants on a protein and that provide association information on a variant-specific level. For details of the implemented method see West, R. M., Lu, W., Rotroff, D. M., Kuenemann, M., Chang, S-M., Wagner M. J., Buse, J. B., Motsinger-Reif, A., Fourches, D., and Tzeng, J-Y. (2019) .

Maintainer: Shannon Holloway
Author(s): Rachel Marceau West, Shannon T. Holloway

License: GPL-2

Uses: CompQuadForm, Matrix, rARPACK

Released 11 months ago.



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