PSM (0.8-8)

Non-Linear Mixed-Effects modelling using Stochastic Differential Equations..

This package provides functions for estimation of linear and non-linear mixed-effects models using stochastic differential equations. Moreover it provides functions for finding smoothed estimates of model states and for simulation. The package allows for any multivariate non-linear time-variant model to be specified, and it also handles multidimensional input, co-variates, missing observations and specification of dosage regimen.

Maintainer: Stig Bousgaard Mortensen
Author(s): Stig Bousgaard Mortensen <> and Søren Klim <>

License: GPL (>= 2)

Uses: deSolve, MASS, numDeriv, ucminf
Reverse suggests: ctsem

Released about 7 years ago.