RNOmni (0.3.0)

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Omnibus Test for Genetic Association Analysis using the Rank Normal Transformation.

http://cran.r-project.org/web/packages/RNOmni

Implementation of genetic association tests based on the rank based inverse normal transformation (INT). The primary contribution is an omnibus test, which synthesizes two complementary INT-based approaches. In simulations against phenotypes with skewed and heavy tailed residual distributions, the omnibus test provided valid inference in the absence of a genotypic effect, and provided power comparable to the more powerful of the component methods in the presence of a genotypic effect. Under these settings, standard linear regression often failed to control the type I error.

Maintainer: Zachary McCaw
Author(s): Zachary McCaw [aut, cre]

License: GPL-3

Uses: abind, foreach, mvtnorm, plyr, Rcpp, ggplot2, reshape2, knitr, rmarkdown

Released 2 days ago.


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