RNOmni (0.6.0)

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Rank Normal Transformation Omnibus Test.


Implementation of genetic association tests that incorporate the rank-based inverse normal transformation (INT). These tests are broadly indicated for traits with continuous residual distributions. In the presence of non-normal residuals, INT-based tests robustly control the type I error, whereas standard linear regression may not. Moreover, INT-based tests dominate standard linear regression in terms of power. There are two main strategies for incorporating the INT in association analysis. In direct INT (D-INT), the trait is directly transformed. In indirect INT (I-INT), residuals are formed prior to transformation. Neither D-INT nor I-INT is uniformly most powerful. The INT omnibus test (O-INT) adaptively combines D-INT and I-INT into a single robust and statistically powerful approach.

Maintainer: Zachary McCaw
Author(s): Zachary McCaw [aut, cre]

License: GPL-3

Uses: abind, foreach, plyr, Rcpp, ggplot2, reshape2, knitr, rmarkdown, cowplot

Released 9 days ago.

10 previous versions



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