SimDissolution (0.1.0)

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Modeling and Assessing Similarity of Drug Dissolutions Profiles.

Implementation of a model-based bootstrap approach for testing whether two formulations are similar. The package provides a function for fitting a pharmacokinetic model to time-concentration data and comparing the results for all five candidate models regarding the Residual Sum of Squares (RSS). The candidate set contains a First order, Hixson-Crowell, Higuchi, Weibull and a logistic model. The assessment of similarity implemented in this package is performed regarding the maximum deviation of the profiles. See Moellenhoff et al. (2018) for details.

Maintainer: Kathrin Moellenhoff
Author(s): Kathrin Moellenhoff

License: GPL (>= 2)

Uses: alabama, dplyr, mvtnorm

Released 4 months ago.



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