crmPack (0.2.7)

Object-Oriented Implementation of CRM Designs.

Implements a wide range of model-based dose escalation designs, ranging from classical and modern continual reassessment methods (CRMs) based on dose-limiting toxicity endpoints to dual-endpoint designs taking into account a biomarker/efficacy outcome. The focus is on Bayesian inference, making it very easy to setup a new design with its own JAGS code. However, it is also possible to implement 3+3 designs for comparison or models with non-Bayesian estimation. The whole package is written in a modular form in the S4 class system, making it very flexible for adaptation to new models, escalation or stopping rules.

Maintainer: Daniel Sabanes Bove
Author(s): Daniel Sabanes Bove <>, Wai Yin Yeung <>, Giuseppe Palermo <>, Thomas Jaki <>

License: GPL (>= 2)

Uses: GenSA, ggplot2, gridExtra, MASS, mvtnorm, rjags, R2WinBUGS, Rcpp, RcppArmadillo, ggmcmc

Released 8 days ago.