crmPack (1.0.0)

Object-Oriented Implementation of CRM Designs.

Implements a wide range of model-based dose escalation designs, ranging from classical and modern continual reassessment methods (CRMs) based on dose-limiting toxicity endpoints to dual-endpoint designs taking into account a biomarker/efficacy outcome. The focus is on Bayesian inference, making it very easy to setup a new design with its own JAGS code. However, it is also possible to implement 3+3 designs for comparison or models with non-Bayesian estimation. The whole package is written in a modular form in the S4 class system, making it very flexible for adaptation to new models, escalation or stopping rules.

Maintainer: Giuseppe Palermo
Author(s): Daniel Sabanes Bove [aut], Wai Yin Yeung [aut], Giuseppe Palermo [aut, cre], Thomas Jaki [aut]

License: GPL (>= 2)

Uses: GenSA, ggplot2, gridExtra, MASS, mvtnorm, rjags, Rcpp, RcppArmadillo, knitr, ggmcmc

Released 4 months ago.