ddepn (2.2)

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Dynamic Deterministic Effects Propagation Networks: Infer signalling networks for timecourse RPPA data..


DDEPN (Dynamic Deterministic Effects Propagation Networks): Infer signalling networks for timecourse data. Given a matrix of high-throughput genomic or proteomic timecourse data, generated after external perturbation of the biological system, DDEPN models the time-dependent propagation of active and passive states depending on a network structure. Optimal network structures given the experimental data are reconstructed. Two network inference algorithms can be used: inhibMCMC, a Markov Chain Monte Carlo sampling approach and GA, a Genetic Algorithm network optimisation. Inclusion of prior biological knowledge can be done using different network prior models.

Maintainer: Christian Bender
Author(s): Christian Bender

License: GPL (>= 2)

Uses: coda, gam, gplots, graph, igraph, lattice, BoolNet

Released over 6 years ago.

11 previous versions



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