famSKATRC (1.1.0)

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Family Sequence Kernel Association Test for Rare and Common Variants.

https://www.r-project.org
https://www.ncbi.nlm.nih.gov/pubmed/25132070
http://cran.r-project.org/web/packages/famSKATRC

FamSKAT-RC is a family-based association kernel test for both rare and common variants. This test is general and several special cases are known as other methods: famSKAT, which only focuses on rare variants in family-based data, SKAT, which focuses on rare variants in population-based data (unrelated individuals), and SKAT-RC, which focuses on both rare and common variants in population-based data. When one applies famSKAT-RC and sets the value of phi to 1, famSKAT-RC becomes famSKAT. When one applies famSKAT-RC and set the value of phi to 1 and the kinship matrix to the identity matrix, famSKAT-RC becomes SKAT. When one applies famSKAT-RC and set the kinship matrix (fullkins) to the identity matrix (and phi is not equal to 1), famSKAT-RC becomes SKAT-RC. We also include a small sample synthetic pedigree to demonstrate the method with. For more details see Saad M and Wijsman EM (2014) .

Maintainer: Khalid B. Kunji
Author(s): Khalid B. Kunji [aut, cre], Mohamad Saad [aut]

License: GPL (>= 3)

Uses: bdsmatrix, CompQuadForm, coxme, kinship2

Released about 1 month ago.


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