httk (2.0.1)

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High-Throughput Toxicokinetics.

https://www.epa.gov/chemical-research/rapid-chemical-exposure-and-dose-research
http://cran.r-project.org/web/packages/httk

Functions and data tables for simulation and statistical analysis of chemical toxicokinetics ("TK") as in Pearce et al. (2017) . Chemical-specific in vitro data have been obtained from relatively high throughput experiments. Both physiologically-based ("PBTK") and empirical (e.g., one compartment) "TK" models can be parameterized for several hundred chemicals and multiple species. These models are solved efficiently, often using compiled (C-based) code. A Monte Carlo sampler is included for simulating biological variability (Ring et al., 2017 ) and measurement limitations. Calibrated methods are included for predicting tissue:plasma partition coefficients and volume of distribution (Pearce et al., 2017 ). These functions and data provide a set of tools for in vitro-in vivo extrapolation ("IVIVE") of high throughput screening data (e.g., Tox21, ToxCast) to real-world exposures via reverse dosimetry (also known as "RTK") (Wetmore et al., 2015 ).

Maintainer: John Wambaugh
Author(s): John Wambaugh [aut, cre] (<https://orcid.org/0000-0002-4024-534X>), Robert Pearce [aut] (<https://orcid.org/0000-0003-3168-4049>), Caroline Ring [aut] (<https://orcid.org/0000-0002-0463-1251>), Greg Honda [aut] (<https://orcid.org/0000-0001-7713-9850>), Mark Sfeir [aut], Matt Linakis [aut] (<https://orcid.org/0000-0003-0526-2395>), Jimena Davis [ctb], James Sluka [ctb] (<https://orcid.org/0000-0002-5901-1404>), Nisha Sipes [ctb] (<https://orcid.org/0000-0003-4203-6426>), Barbara Wetmore [ctb], Woodrow Setzer [ctb] (<https://orcid.org/0000-0002-6709-9186>)

License: GPL-3

Uses: data.table, deSolve, magrittr, msm, mvtnorm, purrr, survey, truncnorm, R.rsp, RColorBrewer, TeachingDemos, classInt, colorspace, gdata, ggplot2, gmodels, gplots, gtools, ks, reshape, smatr, MASS, stringr, GGally, gridExtra, reshape2, scales, knitr, CensRegMod, EnvStats, dplyr, rmarkdown, cowplot, viridis, ggrepel, forcats

Released about 1 month ago.


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