multtest (2.4.0)

Resampling-based multiple hypothesis testing.

Non-parametric bootstrap and permutation resampling-based multiple testing procedures (including empirical Bayes methods) for controlling the family-wise error rate (FWER), generalized family-wise error rate (gFWER), tail probability of the proportion of false positives (TPPFP), and false discovery rate (FDR). Several choices of bootstrap-based null distribution are implemented (centered, centered and scaled, quantile-transformed). Single-step and step-wise methods are available. Tests based on a variety of t- and F-statistics (including t-statistics based on regression parameters from linear and survival models as well as those based on correlation parameters) are included. When probing hypotheses with t-statistics, users may also select a potentially faster null distribution which is multivariate normal with mean zero and variance covariance matrix derived from the vector influence function. Results are reported in terms of adjusted p-values, confidence regions and test statistic cutoffs. The procedures are directly applicable to identifying differentially expressed genes in DNA microarray experiments.

Maintainer: Katherine S. Pollard
Author(s): Katherine S. Pollard, Houston N. Gilbert, Yongchao Ge, Sandra Taylor, Sandrine Dudoit

License: LGPL

Uses: MASS, survival
Enhances: snow, Rmpi, rpvm
Reverse depends: cp4p, EMA, GExMap, LMGene, MAMA, mutoss, PCS, Shrinkage, Statomica, structSSI
Reverse suggests: cherry, hisemi, mutoss, pi0, sprint

Released almost 10 years ago.