ncar (0.3.1)

Noncompartmental Analysis of Pharmacokinetic Data for CDISC Standardized Parameters.

Conduct a noncompartmental analysis as closely as possible to the most widely used commercial software for pharmacokinetic analysis, i.e. 'Phoenix(R) WinNonlin(R)' . Some features include: 1) Use CDISC SDTM PP domain terms and generate PP domains from DM, EX, and PC domains. 2) Automatic slope selection with the same criterion of WinNonlin(R) 3) Support both 'linear-up linear-down' and 'linear-up log-down' method 4) Calculate partial(interval) AUC with 'linear' or 'log' interpolation method 5) Perform a noncompartmental analysis of CDISC standardized pharmacokinetic dataset (.XPT) For more details on noncompartmental analysis, see the reference: Gabrielsson J, Weiner D. Pharmacokinetic and Pharmacodynamic Data Analysis - Concepts and Applications. 5th ed. 2016. (ISBN:9198299107) *) Acknowledgement: Author thanks for the careful review and valuable input of Dr. Jee Eun Lee.

Maintainer: Sungpil Han
Author(s): Kyun-Seop Bae [aut, cre], Sungpil Han [aut]

License: GPL-3 | file LICENSE

Uses: dplyr, Hmisc, lubridate, measurements, tidyr

Released over 2 years ago.