ofGEM (1.0)

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A Meta-Analysis Approach with Filtering for Identifying Gene-Level Gene-Environment Interactions with Genetic Association Data.


Offers a gene-based meta-analysis test with filtering to detect gene-environment interactions (GxE) with association data, proposed by Wang et al. (2018) . It first conducts a meta-filtering test to filter out unpromising SNPs by combining all samples in the consortia data. It then runs a test of omnibus-filtering-based GxE meta-analysis (ofGEM) that combines the strengths of the fixed- and random-effects meta-analysis with meta-filtering. It can also analyze data from multiple ethnic groups.

Maintainer: Jiebiao Wang
Author(s): Jiebiao Wang, Qianying Liu and Lin S. Chen

License: GPL

Uses: CompQuadForm, forestplot, MASS

Released 12 months ago.



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