surrosurv (1.1.25)

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Evaluation of Failure Time Surrogate Endpoints in Individual Patient Data Meta-Analyses.

Provides functions for the evaluation of surrogate endpoints when both the surrogate and the true endpoint are failure time variables. The approaches implemented are: (1) the two-step approach (Burzykowski et al, 2001) with a copula model (Clayton, Plackett, Hougaard) at the first step and either a linear regression of log-hazard ratios at the second step (either adjusted or not for measurement error); (2) mixed proportional hazard models estimated via mixed Poisson GLM (Rotolo et al, 2019 ).

Maintainer: Stefan Michiels
Author(s): Federico Rotolo [aut], Xavier Paoletti [ctr], Marc Buyse [ctr], Tomasz Burzykowski [ctr], Stefan Michiels [ctr, cre]

License: GPL-2

Uses: copula, eha, lme4, MASS, Matrix, msm, mvmeta, optextras, optimx, parfm, SurvCorr, survival, R.rsp

Released 11 months ago.

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